Hashimoto's thyroiditis pathophysiology

Hashimoto's thyroiditis (HT) is part of a spectrum of thyroid autoimmune conditions and this review provides an update on the latest developments in the field. HT has a genetic predisposition with a number of immune-related and thyroid-specific genes conferring disease susceptibility. However, disen Hashimoto's thyroiditis (HT) is characterized by lymphocytic infiltration of the thyroid gland and production of antibodies that recognize thyroid-specific antigens. The pathogenesis is not yet completely understood. Thyroid cells undergo atrophy or transform into a type of follicular cell rich in mitochondria called Hurthle cell Hashimoto's thyroiditis (HT), the most frequent autoimmune thyroid disorders (AITDs), is the leading cause of hypothyroidism in the iodine-sufficient areas of the world. About 20-30% of patients suffers from HT, whose cause is thought to be a combination of genetic susceptibility and environmental f Autoimmune Hashimoto's thyroiditis, the most common endocrine disorder, is primarily a subclinical disease. Whether or not subclinical hypothyroidism should be treated remains controversial. Recent advances have been made in understanding the molecular nature of the antigens that are the target of the immune system in Hashimoto's thyroiditis Hashimoto disease is a form of hypothyroidism. Hypothyroidism happens when there is too little T3 and T4 in the body. When this happens, there is too much TSH. Another term for Hashimoto disease is autoimmune thyroiditis

Definition / general Autoimmune disease with goiter, elevated circulating antithyroid peroxidase and antithyroglobulin antibodies First described by Hakaru Hashimoto in 1912 (World J Surg 2008;32:688 Hashimoto's disease is an autoimmune disorder that can cause hypothyroidism, or underactive thyroid. With this disease, your immune system attacks your thyroid. The thyroid becomes damaged and can't make enough thyroid hormones. The thyroid is a small, butterfly-shaped gland in the front of your neck Pathophysiology: This is caused by an autoimmune disorder that results in a deficiency of the thyroid hormone and the gland is unable to make sufficient amounts of the thyroid hormone. Hashimoto's thyroiditis. Autoimmune. Thyroid destruction -> hypothyroidism

The Pathogenesis of Hashimoto's Thyroiditis: Further

Hashimoto's thyroiditis (autoimmune thyroiditis) is the most common thyroid disease in humans. It is characterized by autoimmune destruction of the thyroid gland whereby the thyroid parenchyma is diffusely replaced by a lymphocytic infiltrate and fibrotic reaction and, frequently, the formation of lymphoid germinal follicles Hashimoto disease, also called Hashimoto thyroiditis, chronic lymphocytic thyroiditis, chronic autoimmune thyroiditis, or struma lymphomatosa, a noninfectious form of inflammation of the thyroid gland (thyroiditis)

Hashimoto thyroiditis (or Hashimoto's thyroiditis) is characterized by the destruction of thyroid cells by various cell- and antibody-mediated immune processes. It is the most common cause of hypothyroidism in the United States after age 6 years. Hashimoto thyroiditis is part of the spectrum of autoimmune thyroid diseases (AITDs). [ 1] ( Hashimoto's thyroiditis or chronic autoimmune thyroiditis is an autoimmune disease involving progressive thyroid dysfunction due to autoimmune-mediated destruction of the thyroid gland through apoptosis of thyroid epithelial cells

Hashimoto's thyroiditis pathophysiology - wikidoc

Hashimoto's thyroiditis pathophysiology - wikido

Hashimoto's thyroiditis, also Hashimoto's disease, is an inflammatory (autoimmune disorder) of the thyroid gland that causes hypothyroidism Hashimoto's thyroiditis overview presentation.(Recorded with http://screencast-o-matic.com)Follow me on Instagramhttp://instagram.com/SimpsonNutritionConnect.. For the encephalopathy, see Hashimoto's encephalopathy. Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis and Hashimoto's disease, is an autoimmune disease in which the thyroid gland is gradually destroyed. Early on, symptoms may not be noticed. Over time, the thyroid may enlarge, forming a painless goiter The pathophysiology of Hashimoto thyroiditis involves the formation of antithyroid antibodies that attack the thyroid tissue, causing progressive fibrosis. The diagnosis can be challenging, and consequently, the condition is sometimes not diagnosed until late in the disease process In the past, the pathology of Hashimoto's thyroiditis was considered to be uniform, but more recently, the histology has varied. 16 Hence, several histological subtypes of Hashimoto's.

Hashimoto's thyroiditis. An autoimmune disease. MC cause of Hypothyroidism Gross: The gland is diffuse symmetrically enlarged, sometimes nodular.Cut surface is fleshy and resembles lymphnode Microscopy: The most prominent feature is extensive lymphocytic infiltrate with formation of germinal centers. As a consequence of destruction, the follicles show varying degree of atrophy Hashimoto's thyroididtis Most common cause of hypothyroidism in areas where iodine levels are sufficient. Gradual thyroid failure due to autoimmune destruction of thyroid gland Definition:It is Characterized by. 1. Diffuse goitrous enlargement of the thyroid 2. Lymphocytic infiltration of the thyroid gland 3. Presence of thyroid autoantibodies Hashimoto's Thyroiditis, also referred to as chronic lymphocytic thyroiditis or autoimmune thyroiditis, is a condition in which one's immune system attacks its own thyroid gland. Along with having an autoimmune basis, it appears to have a genetic disposition playing a factor in the etiology

Hashimoto thyroiditis is autoimmune inflammation of the thyroid. Patients sometimes have other autoimmune disorders. Thyroxine (T4) and thyroid-stimulating hormone (TSH) levels initially are normal, but later, T4 declines and TSH rises, and most patients become clinically hypothyroid. There are high levels of thyroid peroxidase antibodies and. Now, Hashimoto's thyroiditis is an autoimmune disease, meaning that the immune system goes rogue and starts attacking our own follicular cells in the thyroid. The exact trigger for this response is unknown, but there does seem to be a genetic component WebPathology is a free educational resource with 11167 high quality pathology images of benign and malignant neoplasms and related entities. Hashimoto Thyroiditis with a dominant nodule. Hashimoto Thyroiditis - Fibrous Variant. Hashimoto Thyroiditis - Fibrous Variant. Hashimoto Thyroiditis

Autoimmune Hashimoto's thyroiditis, the most common endocrine disorder, is primarily a subclinical disease. Whether or not subclinical hypothyroidism should be treated remains controversial. Recent advances have been made in understanding the molecular nature of the antigens that are the target of the immune system in Hashimoto's thyroiditis. The microsomal antigen is now recognized to. Hashimoto Thyroiditis. Lymphocytic and Hashimoto thyroiditis represent different phases of autoimmune thyroiditis. The initiating factor may be a thyroid-specific defect in suppressor T lymphocytes causing a breakdown in tolerance to self thyroid auto-antigens. There is cellular and antibody-mediated (humoral) immune injury to the gland Hashimoto's Thyroiditis: Pathogenesis and Clinical Findings | Calgary Guide. Endocrinology. Thyroid Disorders (High TSH) Hashimoto's Thyroiditis: Pathogenesis and Clinical Findings

The diagnosis of Hashimoto's thyroiditis may be made when patients present with symptoms of hypothyroidism, often accompanied by a goiter (an enlarged thyroid gland) on physical examination, and laboratory testing of hypothyroidism, which is an elevated thyroid stimulating hormone (TSH) with or without a low thyroid hormone (Free thyroxine [Free T4]) levels Hashimoto's thyroiditis is an autoimmune condition that is a common cause of hypothyroidism. In Hashimoto's thyroiditis, the body mounts an immune reaction against its own thyroid gland tissue, leading to inflammation of the gland (thyroiditis). Thyroid gland is an endocrine gland. It secretes triiodothyronine (T3) and its prohormone, thyroxine. Background: Hashimoto's thyroiditis (HT) has been found to coexist with differentiated thyroid cancer (DTC) in surgical specimens, but an association between the two conditions has been discounted by the medical literature. Therefore, we performed this study to determine any potential relationship between HT and the risk of developing DTC. Methods: We collected data for thyrotropin (TSH.

Symptoms and signs of hypothyroidism based on specific

Hashimotos' thyroiditis: Epidemiology, pathogenesis

  1. This review of literature attempts to identify the factors that are involved in the pathogenesis of Hashimoto thyroiditis, an immune defect in an individual with genetic susceptibility accompanied with environmental factors. The frequency of Hashimoto's disease is a growing trend and among Caucasians it is estimated at approximately 5%
  2. Hashimotos Thyroiditis, Manic Depression, Psychosis and Psychiatric Manifestations by Jeffrey Dach MD. Pathophysiology of Hashimoto's. Hashimoto's thyroiditis is an autoimmune disease in which the thyroid gland is infiltrated by lymphocytes which attack and destroy the functioning thyroid cells called thyrocytes
  3. Chronic autoimmune thyroiditis. Grave's disease. Chronic lymphocytic thyroiditis (Hashimoto's thyroiditis) is a classic example of the organic specific autoimmune disease. Other thyroid diseases are Transient thyroiditis syndrome and idiopathic hypothyroidism. There are 1 to 2% of populations in the UK, and the USA has thyroid diseases
  4. Hashimoto's disease (also known as chronic lymphocytic thyroiditis or chronic auto-immune thyroiditis) is an autoimmune condition characterized by the infiltration of the thyroid by lymphocytes.
  5. Abstract. Painful Hashimoto thyroiditis (pHT) is a rare diagnosis, and optimal treatment remains unclear. To better characterize pHT, PubMed, Embase, Scopus, and Web of Science indexes were searched for case reports or case series reporting pHT, published between 1951 and February 2019
  6. Definition / general. 10 - 12% of all cases. Large symptomatic goiter, marked hypothyroidism. Fibrous atrophy variant: Similar to fibrous variant but thyroid gland is much smaller (1 - 6 g) Elderly patients with marked hypothyroidism and high titers of antithyroid antibodies

Hashimoto's Thyroiditis - Atrophic Follicles Lymphocytic Infiltrate. 10X H&E: The histological section at 10X magnification using H&E stain shows atrophic follicles with Hurthle cell change and dense lymphocytic infiltrate in the stroma. Image Courtesy Ashraf Khan MD. Department of Pathology, University of Massachusetts Medical School. 99401. Ultrastructural pathology in Hashimoto's thyroiditis. Shamsuddin AK, Lane RA. Ultrastructural studies of the thyroid tissue in two cases of Hashimoto's thyroiditis demonstrated that the inflammatory cells do not pass through the follicular cells. Indeed these cells travelled between the epithelial cells in a manner similar to the neutrophil. Hashimoto's thyroiditis 1. HASHIMOTO'STHYROIDITIS Dr. Sangita 2. CASE 48 yrs; Female Midline neck swelling,painless & diffuse, gradually increasing in size x2mths Fatigue, depression, constipation, wt gain, cold intolerance, dry &coarse hair and skin The pathophysiology of the infection is still uncertain, but some pathologies have been associated after contact with the SARS-CoV-2 virus, mainly of an autoimmune nature.7 The present report describes the case of a patient, who became infected with SARS-CoV-2 and after remission of the condition, developed Hashimoto's thyroiditis. Thus, we.

Pathophysiology of Hashimoto's Thyroiditis and

Hashimoto Thyroiditis. Thomas Heineman 0 % Topic. Review Topic. 0. 0. N/A. N/A. Questions. 2. 0. 0. 0 % 0 % Evidence. 2. 0. 0. Topic Introduction: A condition characterized by the autoimmune destruction of the thyroid ; Pathophysiology . the inflammatory reaction is a combination type II and type IV hypersensitivity reactio THE PATHOLOGY OF HASHIMOTO'S THYROIDITIS 2 Primary Pathologic Process Hashimoto's thyroiditis is a clinical picture that derives from reduced activity of the thyroid gland. The thyroid hormones (T4 and T3), whose synthesis is regulated by the TSH secreted in the pituitary gland, have the fundamental mission of regulating the body's metabolic reactions (Guan et al., 2019) CHAPTER 9 Hashimoto's thyroiditis Contents 1. Western medical aetiology and pathology 157 2. Diagnosis by Western medicine 158 3. Chinese medicine aetiology and pathology 158 4. General treatment principle 159 Differentiation and treatment 159 1. Spleen Qi deficiency 159 2. Spleen Qi deficiency with Liver Qi stagnation 160 3. Qi deficiency and Blood stasis 16 Pathophysiology. Acute suppurative thyroiditis is rare in childhood because the thyroid is remarkably resistant to hematogenously spread infection. Most cases of acute thyroiditis involve the left lobe of the thyroid and are associated with a developmental abnormality of thyroid migration and the persistence of a pyriform sinus from the pharynx.

Pathophysiology and Clinical Presentation: Correct

Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis and Hashimoto's disease, is an autoimmune disease in which the thyroid gland is gradually destroyed. Early on, symptoms may not be noticed. Over time, the thyroid may enlarge, forming a painless goiter. Some people eventually develop hypothyroidism with accompanying weight gain, fatigue, constipation, depression, hair loss. It's also called Hashimoto's thyroiditis, chronic lymphocytic thyroiditis or autoimmune thyroiditis. The thyroid gland makes hormones that control virtually all of the body's metabolic functions (how the body turns food into energy) and keep it working normally. Hashimoto's thyroiditis is a type of autoimmune disease — your immune. Ontology: Hashimoto Disease (C0677607) Definition (NCI_NCI-GLOSS) An autoimmune condition of the thyroid gland (a gland located beneath the larynx). It is caused by the formation of antibodies that attack the thyroid gland and it usually causes hypothyroidism (too little thyroid hormone). Symptoms include fatigue, weight gain, constipation, dry.

Pathology Outlines - Hashimoto thyroiditi

  1. The course of thyroiditis depends on the type of thyroiditis. Hashimoto's Thyroiditis - Patients usually present with hypothyroidism, which is frequently permanent.. Painless and Post-Partum Thyroiditis - These disorders are similar and follow the same general clinical course of thyrotoxicosis followed by hypothyroidism. The only real difference between them is that postpartum.
  2. Hashimoto encephalopathy (HE) is an uncommon syndrome associated with Hashimoto thyroiditis (HT). Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) and a more general term, nonvasculitic autoimmune meningoencephalitis, are also used to describe this condition. Originally described in 1966, it remains a.
  3. Investigations. Hashimoto's thyroiditis is based on clinical findings in combination with histological appearance. The thyroid gland shows diffuse lymphocytic and plasma cell infiltration with formation of lymphoid follicles from follicular hyperplasia and damage to the follicular basement membrane [].Atrophy of the thyroid parenchyma is usually evident
  4. Hashimoto's thyroiditis was the sole pathological finding in 462 cases; it accompanied other thyroid pathologies in the remaining 405 cases. The most commonly associated pathology was papillary thyroid cancer, an association that increased significantly during the last two decades

Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease and the most common cause of hypothyroidism. This condition was first described in 1912 by Hakaru Hashimoto, a Japanese surgeon and pathologist ().The pathology is characterized by diffuse lymphocyte infiltration, fibrosis, and parenchymal atrophy Hashimoto's Thyroiditis: Causes, Symptoms, and Support Strategies Hashimoto's thyroiditis is an autoimmune condition that leads to an underactive thyroid and consequent symptoms. Though it is the most common in middle-aged women, Hashimoto's may affect anyone, men, and women at any age, including children and teens Tutorial contains images and text for pathology education. This high power microscopic view of the thyroid with Hashimoto's thyroiditis demonstrates the pink Hürthle cells at the center and right. The lymphoid follicle is at the left. Hashimoto's thyroiditis initially leads to painless enlargement of the thyroid, followed by atrophy years later In this video we will study the gross morphology and histopathology of hashimotos Thyroiditis and Subacute Granulomatous Thyroiditis

Hashimoto's Disease NIDD

Hashimoto Thyroiditis, also known as Chronic Lymphocytic Thyroiditis, represents the most common etiological cause of thyroiditis. Etiology. Hashimoto Thyroiditis is an autoimmune disease whose development likely depends on complex genetic and environmental factors. The disease occurs more frequently in women and in those with the HLA-DR5 allele Hashimoto's thyroiditis can cause your thyroid to not make enough thyroid hormone. It is an autoimmune disease. It occurs when your body makes antibodies that attack the cells in your thyroid. Symptoms may include an enlarged thyroid gland (goiter), tiredness, weight gain, and muscle weakness

Hashimoto's thyroiditis is an autoimmune disease that attacks the thyroid, causing chronic inflammation of the thyroid and often hypothyroidism. Experts believe that up to 90% of people diagnosed with hypothyroidism actually have Hashimoto's. Hashimoto's disease damages the tissue of the thyroid gland, and it can cause a myriad of. Hakura Hashimoto described Hashimoto's Thyroiditis (HT) in 1912. In HT, there occurs formation of antibodies against the self (thyroid), which causes enlargement of the thyroid gland as a whole. hashimoto thyroiditis โรค Hashimoto thyroiditis เป็นการตั้งชื่อโรคเพื่อเป็นเกียรติแก่แพทย์ชาวญี่ปุ่นชื่อ DR.HAKAR 1. Mayo Clin Proc. 1971 Oct;46(10):682-9. Hyperthyroidism associated with histologic Hashimoto's thyroiditis. Fatourechi V, McConahey WM, Woolner LB It is about 100 years since the publication of the original description of the disorder now termed as Hashimoto's thyroiditis (HT) or Hashimoto's disease. Hashimoto's thyroiditis has been commonly considered as a well‐defined clinicopathological entity, characterized by the presence of goiter and serum thyroid autoantibodies

6 Causes of Hashimoto's Disease (and How to Supplement Right)

01.08 Nursing Care and Pathophysiology for Hashimoto's ..

Fibrous variant of Hashimoto's thyroiditis is a rare condition occurring in about 10% cases, mainly middle age people. It is characterized by an extensive fibrous proliferation without extension into the surrounding structures. A 55-year-old female was referred to our department for an unexplained onset of cervical discomfort. She presented a voluminous goiter of hard consistence, dyspnea. - An autoimmune disease characterized by infiltration of leukocytes and progressive destruction of the thyroid gland - Mostly affects young and middle-aged women - Gradual replacement of thyroid tissue with lymphocytes and fibrous (scar) tissu

Hashimoto's Thyroiditis - an overview ScienceDirect Topic

Complex genetic background: HLA-DR5, HLA-DR3, CTLA4, protein tyrosine phosphatase-22 (PTPN22) Autoantibody against multiple thyroid proteins, anti-thyroid peroxidase and anti-thyroglobulin antibodies Autoimmune destruction of follicular cells by activated CD8+ T cells, cytokine-mediated process or autoantibodie Hashimoto's thyroiditis, also referred to as Hashimoto's disease, is an autoimmune disease in which the body attacks its own thyroid gland. White blood cells and antibodies are produced which mistakenly attack the cells of the thyroid gland, thus causing the characteristic symptoms of this common disease But the TPO antibody test isn't positive in everyone with Hashimoto's thyroiditis. Many people have TPO antibodies present, but don't have a goiter, hypothyroidism or other problems. In the past, doctors weren't able to detect an underactive thyroid (hypothyroidism), the main indicator of Hashimoto's disease, until symptoms were fairly advanced 2021 Student Scholarship - Third Place Case Study PRINCESS BURNETT JENNIFER GREEN, ND Hashimoto's thyroiditis is an inflammatory autoimmune disease in which the immune system forms antibodies to thyroid peroxidase and thyroglobulin. The resulting T and B lymphocytic infiltration and inflammation causes scarring and destruction of tissue within the thyroid gland, as well as impaired thyroid. Hashimoto's thyroiditis affects up to 2% of the general population [21] , and afflicts women ten-fold more than in men. The National Health and Nutrition Examination Survey III estimated the prevalence of subclinical and clinical hypothyroidism to be 4.6% and 0.3% respectively [22]

Hashimoto disease pathology Britannic

Hashimoto Thyroiditis: Practice Essentials, Background

Hashimoto's thyroiditis is an autoimmune disease of the thyroid gland. As an autoimmune disease, Hashimoto's results in inflammation and destruction of the thyroid gland which sits at the base of your neck. It is felt that this inflammation will eventually lead to some permanent destruction of the thyroid gland 6 Stages of Hashimoto's Thyroiditis. I've mentioned it before but it's worth repeating here: Hashimoto's thyroiditis is the #1 cause of low thyroid in the United States (1).. It is estimated that as many as 90% of all cases of low thyroid are caused by autoimmune disease of the thyroid gland (AKA Hashimoto's) ulting from environmental factors results in expression of new or hidden epitopes that leads to proliferation of autoreactive T and B cells. Infiltration of thyroid by these cells results in HT. In addition to the usual type of HT, several variants such as the fibrous type and Riedal thyroiditis are also recognized. The most recently recognized variant is immunoglobulin G4+ HT, which may occur. Hashimoto disease, also known as Hashimoto's thyroiditis, is an autoimmune disease. This means your immune system, which normally protects your body and helps fight disease, produces antibodies which attack the thyroid gland. The damaged thyroid gland is less able to make thyroid hormone and this results in hypothyroidism

Hashimoto's Thyroiditis อาจใช้เวลานานหลายปีก่อนจะแสดงอาการ ทำให้ผู้ป่วยไม่ทราบว่าตนเองมีอาการของโรคดังกล่าว โดยสัญญาณบ่งชี้ของโรค. There is a genetic predisposition for Hashimoto's thyroiditis, as patients with human leukocyte antigen (HLA) class I and class II (HLA-DR3, HLA-DR4, HLA-DR5), polymorphisms in the region of the cytotoxic T lymphocyte antigen 4 (CTLA-4) gene on chromosome 2q33 or on chromosomes 6p, 13q32, 12q22 are more susceptible to the development of Hashimoto's thyroiditis [] Thyroiditis is when your thyroid gland becomes irritated. Hashimoto's thyroiditis is the most common type of this health problem. It is an autoimmune disease. It occurs when your body makes antibodies that attack the cells in your thyroid. The thyroid then can't make enough of the thyroid hormone Overview. Hashimoto's thyroiditis (HT) is the most common cause of hypothyroidism in adolescence and mainly affects females. Being the archetype of an organ-specific T-cell-mediated disease, it is characterized by lymphocytic infiltration of the thyroid gland, damage to the thyroid follicular cells, and impaired ability to produce thyroid hormones

Video: Hashimoto thyroiditis - Knowledge @ AMBOS

What is the pathogenesis of Hashimoto thyroiditis

Introduction. Hashimoto thyroiditis (HT) is a form of chronic autoimmune thyroiditis.1 It was first recognised in 1912 by Hashimoto, who described four women with enlarged thyroid glands that showed abundant lymphocytic infiltration (struma lymphomatosa).2 The patients typically present with an enlarged thyroid gland but may also manifest with symptoms and signs of hypothyroidism, particularly. Hashimoto's thyroiditis is____1___and is 5-10 times more common in_____ 1) hereditary 2) women. In the final stage of Hashimoto's thyroiditis, Autoreactive T cells accumulate in large numbers and infiltrate the thyroid, while activated macrophages destroy thyroid cells

Hashimoto's thyroiditis - SlideShar

Thyroiditis is a group of inflammatory thyroid disorders. Patients with chronic lymphocytic thyroiditis (also referred to as Hashimoto's thyroiditis) present with hypothyroidism, goiter, or both Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis and Hashimoto's disease, is an autoimmune disease in which the thyroid gland is gradually destroyed. Early on there may be no symptoms. Over time the thyroid may enlarge, forming a painless goiter. Some people eventually develop hypothyroidism with accompanying weight gain, feeling tired, constipation, depression, and.

Hashimoto thyroiditis (HT) known also as chronic lymphocytic thyroiditis is an autoimmune disease microscopically featuring diffuse lymphoplasmacytic inflammation with lymphoid follicles containing germinal centres, follicular epithelial damage, epithelial atrophy, oncocytic and rarely squamous metaplasia and fibrosis [].A close relation of inflammation and cancer was noticed in many studies An exciting pilot study improved the quality of life and symptoms of women with Hashimoto's thyroiditis who used the AIP diet for 10 weeks . Their tests showed no significant changes to any measures of thyroid function or antibodies, but their inflammation decreased by 29%. Pathophysiology and laboratory diagnosis of pernicious anemia. Hashimoto's thyroiditis is a chronic (ongoing) condition where the body's immune system attacks the thyroid, a gland in the neck that makes thyroid hormone.. More to Know. The thyroid hormone helps the body handle many chemical reactions, controls how the body converts food into energy, and helps direct growth and sexual development.. In someone with Hashimoto's, often the thyroid must work. Hashimoto's encephalopathy, also known as steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), is a neurological condition characterized by encephalopathy, thyroid autoimmunity, and good clinical response to corticosteroids.It is associated with Hashimoto's thyroiditis, and was first described in 1966.It is sometimes referred to as a neuroendocrine disorder.